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Kabi R. Neupane, Ph.D.
Instructor, Biology and Biotechnology, LCC, Hawaii
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Kabi R. Neupane, Ph.D. Instructor, Biology and Biotechnology, LCC, Hawaii
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BIOLOGY 201 Spring Semester 2002 Room: MS 105 Instructor: Kabi R. Neupane;
Office: MS 107;
Email: Kabi @hawaii.edu Lecture
hours: MWF Office hours: MWF ( Internet: http://emedia.leeward.hawaii.edu/kabi WebCT: http://webct.hawaii.edu Grace
E. S. (1997) Biotechnology Unzipped: Promises and Realities. Joseph Henry
Press You can read this book for
free at: http://print.nap.edu/pdf/0309057779/pdf_image/ Credit in at least one 3
credit 100-level biological sciences course or consent of instructor and a grade
of 'C' or better in Eng 21 or Eng 22. Biotechnology and society
(Credit 3) - Introduction to the basic concepts, goals and practical impacts of
biotechnology. Real-life case
studies are used to explore socio-ethical, economic and environmental issues
raised by cloning, DNA testing, gene therapy and genetically engineered food,
medicines and vaccines using microbes, plants and animals. Upon successful completion
of the course the student shall be able to: 1. Define the term
"biotechnology," and access current research in the field. 2. Describe the
characteristics of DNA, and explain its uses in biotechnology.
3.
Explain basic principles and concepts of biotechnology including concepts
of gene expression, recombinant DNA methodology, cloning and genetic
engineering. 4. Define and explain DNA
probes, DNA fingerprinting, and DNA amplification. 5. Explain the function of the
healthy immune system, the concept of genetic disease, and the application of
gene therapy to genetic disease. 6. Define the term
"designer drug," and explain the pros and cons of synthetically or
genetically engineering pharmaceuticals. 9. Define the term
"bioremediation," and explain the advantages and disadvantages of
applying biotechnological solutions to environmental problems. 10. Explain opportunities in marine biotechnology.
SCHEDULE
CHANGE: I may change the order or
content of the lectures and/or labs if I feel that such change(s) will benefit
the class. You will be informed in advance of changes, if any. The examinations will cover
material presented in lectures, videos and the text. The emphasis of each exam
will be on material covered in class. The exams' format will be multiple choice,
short answer, and short essays. You
are strongly urged to attend each class and continually review the text and
lecture notes. Distribution
of points: 3 lecture exams (100 to 150
points
each)
350 Group Report
200 Individual Presentation
100 Final Examination
150 Total
800 The final exam will be
cumulative. You will need to purchase your own Scantron forms from the bookstore
(15 cents each) for the tests and final exam.
If you forget to bring a Scantron to the test, you may buy one from the
Instructor for $1.00. However, any
and all tests, except the lab examination, may be taken over the WebCT. There
will be one laboratory test at the end. Please note that the last
day to withdraw from the course without “W” is February
3, 2003 and it is your responsibility to drop
the course by that date. Simply stopping to come to the class will result in an
F for the course. An I grade is
given only under extreme circumstances. There
will be no make-up exams unless under extreme circumstances or prior arrangement
with the instructor. However, there will be no make-up lab examination. Students with disabilities
who believe that they may need accommodations in this class are encouraged to
contact the Coordinator of the KÄKO‘O ‘IKE (KÏ) program located in L-208
of Leeward Community College’s library building as soon as possible to ensure
that such accommodations are implemented in a timely fashion. Day
Date Lecture
topic Section
I: Introduction, Origins & Tools of Biotechnology. (Chapters 1 & 2) Mon
1/13 Introduction to Biotechnology, Definition, Historical
perspective, Challenges for the 21st Century, Social Impact
Wed 1/15
Overview of Socio-ethical Impacts,
Introduction to Cell Structure,
Fri 1/17
More on cell and DNA
structure. How does a gene code for
a protein?
Mon 1/20
Martin Luther King Jr. Day ( Wed 1/22 Bacteria,
Phages, plasmids, restriction enzymes Fri 1/24
Cloning a gene is different than cloning plants, animals, cells Mon 1/27
More on cloning plants, animals, cells
Wed 1/29 Molecular
Diagnostics: Antibodies, Monoclonals, ELISAs
Fri
1/31 Molecular
Diagnostics: DNA/RNA probes,
primers. REPORT GROUPS Mon 2/3 Molecular Diagnostics: DNA
fingerprinting, RFLP, forensics Wed
2/5 Molecular Diagnostics: PCR
and applications Fri 2/7
Pre-implant Genetic Diagnostics, Socio-ethical Issues Mon 2/10
******** Exam 1 ******** (150 points)
Section
II: Biotechnology
and People and agriculture (Chapter 3 and 4) Wed 2/12
Human
Genetic Diseases, stem cells, Intro to Gene Therapy
Fri 2/14
Human Gene Therapy
Mon 2/17
Presidents Day ( Wed 2/19
Human
Genome Project, TOPIC SELECTION DUE
Fri 2/21
Issues in Health care: Double-Edged Sword
Wed 2/26
More on Genes & Vaccines, Tryptophan Case
Fri 2/28
Introduction, BST &
Milk; Pesticides, Herbicide Resistance; Regulations
Wed 3/5
What is Bt? Engineering a
plant with the Bt gene Fri 3/7
Viruses & Plants;
Engineered Coat Protein Resistance; Rainbow Papaya
Wed 3/12
Freezing tolerance ;
Soil bacteria and fertilizer
Fri 3/14 AgBiotechnology Case Studies Video Mon
3/17 ********
Exam 2 ******** (100 points)
Section
III:
Environment, Marine and Wed
3/19
Concerns about release of GMO's, bacteria, pollen
Fri 3/21
Microbes & Bioremediation
Mon 3/31
Microbes, Mines & Mining Wed
4/2
Aromatic Hydrocarbons ,
Biofuels Fri 4/4
An ocean of opportunity, New drugs and medicines from the ocean Mon 4/7
Fuels from the sea Wed 4/9
Fish and Biotechnology
Fri 4/11
Biotechnology and Trees
Mon 4/14
******** EXAM 3 ******** (100%)
Section
VII: Overview of Social Impacts and
Ethical Issues Wed 4/16
Commercialization, Introduction , Intellectual Property Rights,
Patents Fri 4/18
Good Friday ( Mon 4/21
Issues around Patenting Wed 4/23 Government
Regulation I, NIH, EPA, FDA, USDA
Fri 4/25
Biotechnology in the media GROUP PROJECTS DUE Mon 4/28
Student Presentations
Wed 4/30 Student
Presentations Fri 5/2
Student Presentations
Wed
5/14 FINAL
EXAMINATION:
7:45am to 9:45am (150 POINTS; CUMULATIVE) GROUP
PROJECTS AND INDIVIDUAL PRESENTATION 1.
Group Project (150 points): Students
will work in small groups to select biotechnology articles impacting society.
The articles should be recently published in refereed journals, or reputable
magazines and newspapers. Each
article shall be thoroughly discussed in the group to understand issues and
impacts of the publication. After
the group discussion and articulation of different views, a 2.
Individual Presentation (100 points):
Each student will be required to give an oral presentation on a current issue of
biotechnology. The student will research a topic of his/her interest from
library, the Internet or the text book. Students are encouraged to
contact the instructor in regard to any aspect of the course.
Each student is expected to attend all meetings of this class. Absence
from more than three classes may adversely impact the course grade. Students are
not excused from the exams except in case of personal illness or death in the
immediate family. INDIVIDUAL
ASSIGNMENT:
Individual Presentation on Current Issues in Biotechnology Purpose: To understand one
current subject in biotechnology in depth and communicate it to others. At the end of this course,
each student will give an oral presentation on a current issue in biotechnology.
Select a topic in biotechnology of interest to you.
Turn in your topic by Format:
You will give an 18 minute presentation. There will be five minutes set
aside for questions from the audience, plus a couple minutes for set-up and
introducing the speakers. Feel free to use visual material, overheads, slides,
and the blackboard in your delivery. 1.
Research your subject in the library, text and internet.
Obtain thorough background information, read up on it becoming an expert.
2.
In your presentation, introduce the subject and explain the science
behind it. Explain why it is a type
of biotechnology. 3.
Give examples of the technology in use. 4.
Describe the influence of the technology on society. Are there benefits
and/or disadvantages? 5.
Discuss the following: Is
there controversy associated with the technology? What are the opinions for and
against it? Are the opinions based
on fact? ASSIGNMENT:
Group Project Notebook Purpose:
To realize the broad impact of biotechnology on society, discuss these
impacts with others, articulate concepts to others, listen and understand
others' viewpoints and write a cohesive analysis and essays together as a team. After the first week of
class you will be asked to form in small groups.
If you do not choose a group, the professor will assign you to one.
Turn in the list of members in your group by January 31. The project
notebooks will consist of the following two components: 1.
Three newspaper, magazine, journal or internet articles that focus on the theme
"Impact of Biotechnology on Society".
Try to find articles early in the semester. 2. Four paged, typed (11-12 pt font, Times) double-spaced essays on each
of the articles. (Number each page). 3. A two page summary of your
group activities, detailing highlights and records of your meeting discussions. These articles can be on
any aspect of Biotechnology, such as the scientific principles and research
involved, the problems in society that will be solved and the possible ethical
issues raised. The subject is broad and can include problems in medicine,
agriculture, forestry, ecology, forensics, patent law or socio-ethical issues.
Subjects can be on what Science Chemical Engineering News Wall Street Journal New York Times Nature Nature Biotechnology
California
Agriculture Trends in Biotechnology The World & I Popular Science Time, Newsweek Horticulture Agricultural Research
(USDA) Honolulu
Advertiser Biotechniques Scientific American Discover New Scientist National Geographic Hand in your articles and
three written essays, organized in a notebook.
Notebooks will be graded on originality, quality, concept understanding
and completeness. The group project is due on
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nd mail, questions or comments about
this web site to kabi@hawaii.edu.
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